diethylene glycol monobutyl ether on skin

The presence of acetone in the solution caused a reduction in lag time and an increase in permeation rate, higher for EGMEE, lower for EGDEE, indicating the enhancing effect of this mixture of solvents. There are no studies available of the absorption of diethylene glycol monobutyl ether acetate via inhalation. Use the link below to share a full-text version of this article with your friends and colleagues. OBJECTIVES: The increased use of glycol ethers (GEs) for water-based paints and cleaning products, combined with a lack of information about many of these products, particularly with regard to the effects of percutaneous exposure, led us to evaluate the skin absorption rates of a group of glycol … 2017 Nov;91(11):3587-3596. doi: 10.1007/s00204-017-2046-2. In addition, diethylene glycol accounted for 12% of the radioactivity, a non‐quantified fraction was ethylene glycol and 32% was detected in 2‐(2‐(3‐ or 4‐hydroxybutoxy)ethoxy)ethanol. and you may need to create a new Wiley Online Library account. This product is created when ethylene oxide and n-butanol are combined. There are no studies available with long-term administration of diethylene glycol monobutyl ether acetate. Diethylene Glycol Monobutyl Ether (DB Solvent) sold by Eastman is a high boiling glycol ether used in baking enamels to promote increased flow-out and leveling in paint films. This site needs JavaScript to work properly. Diethylene glycol monobutyl ether had no effect on the mating index, pregnancy incidence or male and female fertility indices after dermal application of 2000 mg/kg body weight and day for 13 weeks. When diethylene glycol butyl ether (DGBE) and diethylene glycol monobutyl ether acetate (DGBEA) were applied to the skin for 5 min then washed, most (90%) of the material was recovered. Background: Diethylene glycol monoethyl ether (DEGEE) is widely used as a solubilizer in cosmetics as well as in oral, topical, transdermal and injectable pharmaceutical formulations. However, ready absorption after inhalation exposure is assumed in analogy to other glycol ethers and glycol acetates (Lundberg 1995). In pesticide products, DEGBE acts as an inert ingredient as a deactivator for formulation before the crop emerges from the soil and as a stabilizer. The authors did not explain this conflicting result. Rinse skin with plenty of water or shower. log KOW A study, that was not available to the OECD in the original but only as a summary, reported slight irritation of rabbit skin after exposure to diethylene glycol monobutyl ether acetate (OECD 2005). DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Candidate List DIETHYLENE GLYCOL MONOBUTYL ETHER For Synthesis is not on the REACH Annex XIV List 15.1.2. There are no data available for the effects after the ingestion of diethylene glycol monobutyl ether acetate. As a result of the inadequate documentation, this study cannot be included in the evaluation. Metabolites of diethylene glycol monobutyl ether acetate. Flammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. After 72 hours, 4% of the radioactivity was still present in the body (Deisinger and Guest 1989). After 10‐minute incubation, a plateau concentration of about 6% of the initial concentration was reached, which remained constant for about 14 minutes (OECD 2005). In a study from 1944, diethylene glycol monobutyl ether acetate was applied dermally to the skin of rabbits (no other details) in doses of 489, 978, 1956 or 3912 mg/kg body weight and day once a day for 90 days. Laboured breathing, reduced activity, increased respiratory rate, anorexia, weakness, tremor and straightened posture were observed in the animals at the high doses (OECD 2005). Please enable it to take advantage of the complete set of features! Molecular Weight 162.23 . Clipboard, Search History, and several other advanced features are temporarily unavailable. In analogy to diethylene glycol monobutyl ether, diethylene glycol monobutyl ether acetate is not classified in any of the categories for carcinogens or germ cell mutagens. Mechanism of action of diethylene glycol monobutyl ether acetate changes were observed in the body ( Deisinger and 1989. As an impurity, ingestion and dermal application of diethylene glycol monobutyl ether acetate is hydrolyzed within minutes. 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